|
KMID : 0603820140200010025
|
|
Journal of Experimental & Biomedical Science
2014 Volume.20 No. 1 p.25 ~ p.31
|
|
|
The Effect of Microbial Extracts on the Cell Activation and Inhibition Associated with Atopic Dermatitis
|
|
Yang Eun-Ju
Chang Jeong-Hyun
|
|
|
Abstract
|
|
|
|
Atopic dermatitis (AD) is an inflammatory, relapsing, chronic skin disease and lesions in AD are frequently colonized with Staphylococcus aureus (S. aureus). Activation of T cells and IgE production by staphylococcal enterotoxins B (SEB) plays a crucial role in the pathogenesis of AD. Enterococcus faecalis (E. faecalis) is a nonpathogenic bacterium and produces the probiotic products that have been shown to have inhibitory effects on inflammatory responses. In present study, we carried out to assess the anti-inflammatory role of lyzed E. faecalis against the damaging effects of SEB on AD related immune responses. Furthermore, we attempted to determine whether the co-cultured lyzed E. faecalis can influence the colonization of S. aureus. As a result, we identified the effect of E. faecalis lysate as a potent therapeutic agent for atopic dermatitis (AD). E. faecalis lysate reduces the productions of total IgE and cytokines of AD-related immune cells in response to SEB stimulation. The proliferation of S. aureus was also inhibited by E. faecalis lysate. n conclusions, E. faecalis lysate may improve the skin-defense system disturbed by atopic condition, and may prevent subsequent secondary infection of S. aureus and development of AD.
|
|
|
KEYWORD
|
|
|
Atopic dermatitis, Staphylococcal enterotoxins B, Enterococcus faecalis, IgE, cytokines
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|